학술저널
2-(4-비페닐일)부티르산의 합성
Facile Synthesis of 2-(4-Biphenylyl)butyric Acid
- 대한약학회
- 약학회지
- 제36권 제2호 (1992년)
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1992.04137 - 139 (3 pages)
- 2
A new method for xenbucin, which is a antihypercholesteremic agent, is described. Friedel-Crafts reaction of biphenyl with ethyl alpha-chloro-alpha-chloro-alpha(methylthio)acetate(1) afforded ethyl 2-methylthio-2(4-biphenylyl)acetate(2). Ethyl 2-(4-biphenylyl)butyric(4) was obtained by ethylation of(2) with NaH and C2H5I, folowed by desulfurization of the resultant ethyl 2-methylthio-2-4-biphenylyl)butyrate(3) with zinc dust in acetic acid. Xenbucin was synthesized by hydrolsis of (4).
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