학술저널
새로운 세파로스포린계의 항생제 합성과 항균성
Synthesis and Antimicrobial Activity of Cephalosporin Antibiotic Derivatives
- 대한약학회
- 약학회지
- 제36권 제2호 (1992년)
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1992.04150 - 158 (9 pages)
- 0
7beta-(5-Aryl-2H-tetrazol-2-yl)acetamidocephalosporanic acid (23~26) and 7beta-(5-Aryl-4-phenyl-4H-1,2,4-triazol-3-yl)thioacetamidocephalosporanic acid were synthesized by condensation of 5-Aryl-2H-tetrazol-2-acetyl choloride(17~20) and 5-Aryl-4-phenyl-4H-1,2,4-triazol-3-thioacetyl chloride(22~24) with 7-Aminocephalosporanic acid (7-ACA), respectively. These seven compounds were tested in vitro antimicrobial activity. These exhibited good antimicrobial activity against Gram-positive bacteria whereas most compounds showed decreased antimicrobial activity against Gram-negative bacteria.
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