테오필린과 페플록사신과의 상호작용

Interaction of Theophylline and Pefloxacin

Pharmacokinetic interaction of theophylline with pefloxacin following iv. administrations was investigated in rabbits. Pefloxacin was coadministrated at doses of 10 and 20mg/kg or previously administered for 6 days 10 and 20mg/kg. Plasma concentration and AUC of theophylline were increased significantly (p<0.05) and the renal clearance (CLr), total body clearance (CLt) and the volume of distribution (Vdss) were decreased significantly (p<0.005) by the pretreatment. It demonstrates that adjustment of dosage regimen of theophylline should be considered when concomitant administration of pefloxacin is prescribed.