가토에서 혈압에 관여하는 약물의 작용에 대한 니페디핀의 영향

Effect of Nifedipine on the Action of Drug Participating in Blood Pressure in Rabbits

In order to investigate the effect of nifedipine, Ca2+ channel antagoninst, on the action of some drugs participating in blood pressure, this experiment was performed in rabbits. Nifedipine decreased the pressor actions of norepinephrine, angiotensin and carotid artery clamping, but did not affect the pressor actions of tyramine and depressor actions of acetylcholine and pilocarpine. Nifedipine inhibited the potentiated pressor action of norepinephrine and angiotensin, but did not influence the potentiated pressor action of tyramine in rabbits pretreated with chlorisondamine, ganglionic blocking agent. Nifedipine weakened the potentiated pressor action of norepinephrine, did not affect the pressor action of angiotensin and the potentiated pressor action of tyramine in rabbits pretreated with debrisoquine, sympathetic neuronal blocking agent.