학술저널
흰쥐에서 할로페리돌에 의해서 유발된 강경증에 미치는 후구 적출의 영향
Effects of Olfactory Bulbectomy on Catalepsy Induced by Haloperidol in Rats
- 대한약학회
- 약학회지
- 제36권 제5호 (1992년)
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1992.10427 - 432 (6 pages)
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We attempted to clarify the effect of bilateral olfactory bulbectomy on catalepsy induced by haloperidol in rats. The incidence of catalepsy induced by haloperidol remarkably increased after lesion of olfactory bulb, which was significantly inhibited by L-5-hydroxytryptophan, L-DOPA, and ginseng''s total saponin but reserpine and alpha-methyl-p-tyrosine were ineffective. The dopamine content of brain was significantly decreased by olfactory bulbectomy, but this result was reversed by ginseng''s total saponin.
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