학술저널
N-(2치환스티릴) 카르복사미드류의 합성
Synthesis of N-(disubstituted styryl) Carboxamides
- 대한약학회
- 약학회지
- 제36권 제5호 (1992년)
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1992.10433 - 439 (7 pages)
- 0
For the synthesis of tuberin derivatives, N-(disubstituted styryl) carboxamides, the series of cinnamic acids were transformed through chlorides, azides to isocyanates. And then isocyanates were reduced separately by Dibal and Grignard reagent. As a result of antimicrobial susceptibility test, N-(3,4-dichlorostyryl) formamide and N-(3,4-dichlorostyrl) acetamide showed comparatively large activity against some bacteria that is, MIC was respectively 50 ppm, 6.25~50 ppm. MIC of other derivatives was similiar to that of tuberin, about 100.
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