노르후록사신-금속이온 착물의 물리화학적 성질 및 항균력

Physiochemicl Properties and Antibacterial Activities of Metal Complexes of Norfloxacin

Norfloxacin complexes of Fe2+, Cu2+ and Al3+ have been prepared as solids. The stoichiometry of the complexes has been established. IR investigation indicates the metal-ligating sites in norfloxacin. The bioactivities of complexes all lower than that of norfloxacin. The solubilities and partition coefficients have been measured as a function of temperature. The data are used to evaluate the thermodynamic parameters deltaG, deltaH, deltaS for the solute transfer process and compared with the parent quinolone, norfloxacin. The existence of such complexes is discussed in the light of quinolone mode-of-action theories.