학술저널
타아조로[3,2-a][1,3]디아제핀-베타인의 고리변환 반응
Ring Transformation Reaction of Thiazolo[3,2-a][1,3]diazepinium-Betaine
- 대한약학회
- 약학회지
- 제37권 제2호 (1993년)
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1993.04113 - 118 (6 pages)
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3-Phenyl-5,6,7,8-tetrahydrothiazolo[3,2-a][1,3]diazepine, which has pharmaceutical activities, was reacted with phenyl isothiocyanate to give 3-phenyl-9-phenyl(thiocarbamoyl)-5,6,7,8-tetrahydrothiazolo[3,2-a][1,3]diazepinium-betaine. New biheterocyclic compounds were prepared by the ring transformation reaction of the above reactive betaine with alpha-haloesters and alpha-haloketones such as ethyl bromoacetate, methyl bromoacetate, chloroacetone, and 4''-methoxyphenacyl bromide, respectively. In each ring transformation reaction, two major products supposed to be geometrical isomers were obtained.
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