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학술저널

베타 락탐계 항생제의 합성 및 항균력

Synthesis of beta-Lactam Antibiotics and Their Antibacterial Activity

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6beta-(trans-3-Aryl-5-oxo-pyrrolidin-2-yl)acetamidopenicillanic acid(7a~7c) and 7beta-(trans-3-Aryl-5-oxo-pyrrolidin-2-yl)acetamidocephalosporanic acid(8a~8c) were synthesized and tested in vitro antibacterial activity. Of these new penicillins exhibited good antibacterial activity against Gram-positive bacteria whereas none of the compounds possessed the activity against Gram-negative bacteria at the concentration tested.

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