학술저널
항진균제 Naftifine 구조와 관련된 알릴아민류의 합성
Synthesis of Naftifine-Related Allylamine as a Potential Antimycotics
- 대한약학회
- 약학회지
- 제37권 제3호 (1993년)
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1993.06247 - 253 (7 pages)
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Eight new derivatives of allylamine which are related to naftifine and expected to have antifungal activity were synthesized. Schiff base 2a-2d and 2''e-2''h were obtained by conventional methods using trans-cinnamylamine or trans-cinnamaldehyde. The reduction of azomethine linkage with NaBH4 yielded secondary amine 3a-3h, which were then methylated by means of HCHO and excess NaBH4 or hcooh to give 4a-4h.
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