오메프라졸과 Hydroxypropyl-beta-cyclodextrin의 포접화합물 형성과 특성

Complexation and Properties of Omeprazole with Hydroxypropyl-beta-cyclodextrin

Inclusion complex of omeprazole(OMZ) with hydroxypropyl-beta-cyclodextrin(HP-beta-CD) was prepared by freeze-drying method. The complexation was confirmed by means of UV, CD, IR, DSC, XRD and 1H-NMR spectra. The benzimidazole moiety of OMZ might be found to be included into the cavity of HP-beta-CD and the inclusion complex appeared to be AL type. The stoichiometric ratio of OMZ : HP-beta-CD was found to be 1 : 1, and the stability constants of the inclusion complex by solubility and UV method were about 34 and 45 M-1, respectively. The dissolution of OMZ was significantly enhanced from powder and. yablet of OMZ-HP-beta-CD complex when compared to those of OMZ alone, and oil-to-water partition coefficient of OMZ-HP-beta-CD complex was significantly higher than that of OMZ alone. Therefore, it was expected that the bioavailability of OMZ could be improved markedly by inclusion complexation of OMZ with HP-beta-CD.