학술저널
Protocatechuic acid 및 Gallic acid 유도체들의 항 혈전작용
Anti-thrombotic Effects of Analogs of Protocatechuic Acid and Gallic Acid
- 대한약학회
- 약학회지
- 제37권 제5호 (1993년)
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1993.10453 - 457 (5 pages)
- 19
Platelet anti-aggregating activities were tested with analogs of protocatechuic acid and garlic acid. Six of them which showed comparable inhibitory effects with aspirin against collagen induced platelet aggregation were selected and their anti-thrombotic effects were evaluated in the mouse thrombosis model and compared with those of aspirin and paeonol. At the dose of 50mg/kg, p.o., ethyl gallate(13) treated group showed higher % of recovery within 6 min of thrombotic challenge and lower mortality within 5 min than aspirin treated group.
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