한국산 고등균류 만가닥버섯의 항암성분

Studies on Constitutents of the Higher fungi of Korea. Antitumor Components of the Basidiocarps of Hypsizigus mamoreus

To find antitumor components in the hot water extract from the basidiocarps of Hypsizigus mamoreus. protein-bound polysaccharides were purified and fractionated by DEAE-cellulose ion exchange column chromatography and Sepharose CL-4B gel filtration chromatography. When a dose of 20mg/kg/day was injected intraperitoneally into ICR mice. fraction IV of the component showed the highest inhibition ratio of 73.8% against the count of hemolytic plaque forming cells in mice to 3.2 times. when IV was about 30 KD and the fraction was composed of 76.1% polysaccharide and 4.9% protein. The hexosamine was detected in all the fractions, showing that the polysaccharide and protein moieties were bound each other.