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항암항생제 11-Deoxy-beta-rhodomycinone의 합성

Total Synthesis of 11-Deoxy-beta-rhodomycinone Antitumor Antibiotics

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Methyl 3-[(phenylsulfonyl)methyl]-1,4,8-trimethoxy-2-naphthoate(7) preparad by 3 steps was condensed with 5-ethyl-2-cyclohexen-l-one(8) to afford the teracyclic aromatic ring system compound 10, which was stepwise converted into the precursor of 11-Deoxy-beta-rhodomycinone by means of various functional groups transformation.

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