학술저널
팔라듐 촉매릴 이용한 퀴놀론핵과 Heteroaryl Stannes의 결합 -C-7 heteroaryl 퀴놀론 유도체의 합성-
Palladium-Catalyzed Coupling between Quinolone Moieties and Heteroaryl Stannes -Synthesis of C-7 heteroaryl Quinolone Derivatives-
- 대한약학회
- 약학회지
- 제37권 제6호 (1993년)
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1993.12615 - 620 (6 pages)
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The cross-coupling reaction of organo tin reagents with a variety of organic halides, catalyzed by palladium, provides a novel method for generating a carbon-carbon bond. We used this method for the antibacterial agents, and synthesis of new quinolone derivatives which have carbon-carbon bond at C-7 position of general quinolone moieties. Aryl tin, quinolone moieties, and palladium catalyst were refluxed in DMF to afford new quinolone derivatives. This palladium catalyzed coupling reactions have capacity for further synthetic elaboration.
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