학술저널
파두와 황련의 수용성 혼합물(CP2)부터 분리된 항암성분의 구조확인 및 세포독성에 대한 연구
Identification of Active Component Isolated from Croton tiglium and Coptis japonica Aqueous Mixture(CP2) and Studies of Its Cytotoxic Effect
- 대한약학회
- 약학회지
- 제38권 제1호 (1994년)
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1994.0231 - 37 (7 pages)
- 4
Active fraction, P2, was isolated from natural anti-cancer drug, CP2, by HPLC. We confirmed that P2, includes most of the Isoguanosine and minor components, Berberine and other protoberberine alkaloids, by 1H-NMR and 13C-NMR and measured the cytotoxicity of P2, against various tumor cell-lines. P2, was very effective to all tumor cell-lines, especially to human colon cancer SNU-C2A(ED50; 24mcg) and liver cancer HEP-3B(ED50; 27mcg).
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