DWP-301 (수산화알루미늄, 수산화마그네슘, Simethicone, Aceglutamide Aluminum)의 흰쥐에 대한 4주간 반복 경구투여 독연구

Toxicity of DWP-301 (Al(OH)3, Mg(OH)2, Simethicone, Aceglutamide Aluminum) to Rats by Repeated Oral Administration for 4 Weeks

Daily oral administration to Sprague Dawly rats for 4 weeks of DWP-301, at doses of 0, 500, 1000, 2000mg/kg presented following results; 1) No animals died and there were no significant differences in general signs, body weight, food consumption, urinalysis haematological, biochemical, gross pathological and histopathological examination between control and treated rats. 2) Water consumption, pH-, protein- urobilinogen-, ketone-values in urine were significantly increased in the treated male and female rats. It is supposed that these differences in animals are a consistent feature of repeated overdosage with test suspensions. The results indicate that the non toxic dose of test compounds in rats is over 2000mg/kg in this test system.