담즙산류과 베타-시이클로덱스트린간의 복합체 형성

Complexation of Bile Acids with beta-Cyclodextrin

From phase solubility studies bile acids and bile salts were found to form stable inclusion complexes with beta-cyclodextrin in aqueous solution. Stability constant of bile acids were larger than that of bile salts. Phase solubility diagrams of most bile acids showed Higuchi''s AL type but lithocholic acid showed Bs type. Not only the solubility of bile acids but also that of beta-cyclodextrin increased, especially in cases of cholic acid and ursodeoxycholic acid. Solubility increase of bile acids from their beta-cyclodextrin inclusion complex followed the order : cholic acid>ursodeoxycholic acid>chenodeoxycholic acid>deoxycholic acid>lithocholic acid. It seems that solubility of inclusion complexes was directly related with the hydrophilicity of bile acids.