우르소데옥시콜린산 및 이의 베타-시클로덱스트린 포접복합체간의 in-vitro 용출, in-vivo 흡수및 이담효과의 비교

Comparison between Ursodeoxycholic Acid and Its beta-Cyclodextrin Inclusion Complex: in-vitro Dissolution, in-vivo Absorption and Choleretic Effect

Choleretic effect and absorption of ursodeoxycholic acid (UDCA) in rats were studied using UDCA alone and it''s beta-cyclodextrin (beta-CyD) inclusin complex (UDCA-IC). In spite of increase in solubility and dissolution rate, absorption of UDCA-IC was decreased compared with UDCA alone. Choleretic effect of UDCA-IC was also decreased. It looks that UDCA forms stronger inclusion complex with beta-CyD than any other drug or organic biological material. From this study, it was suggested that UDCA might be used as a new potential competing agent when inclusion complexes of drugs with beta-CyD were administered for the improvement of poor bioavailability.