학술저널
8-Methyl-8,14-cycloberbine 유도체 합성
Synthesis of 8-Methyl-8,14-cycloberbine Derivatives
- 대한약학회
- 약학회지
- 제38권 제4호 (1994년)
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1994.08451 - 454 (4 pages)
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In accordance with reported references, 8-methyl-8,14-cycloberbine was derived from berberinephenolbetaine. On acidic treatment the 8-methyl-8,14-cycloberbines were converted easily to the compounds 1-7 in good yields. We developed a novel method for a Synthesis of the C8-N bond adduct compounds 8 and 9 from 8-methyl-8,14-cycloberbine by treatment with oxalyl chloride, and 1,3-dichloroaceton.
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