학술저널
항염증제로서 2-아릴-5-벤즈옥사졸프로피온산 유도체의 합성
Synthesis of 2-Aryl-5-benzoxazolepropionic Acid Derivatives as Antiinflammatory Agent
- 대한약학회
- 약학회지
- 제38권 제5호 (1994년)
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1994.10504 - 510 (7 pages)
- 6
A facile synthesis of 2-aryl-5-benzoxazolepropionic acid derivatives(10a-d), which are potent antiinflammatory agent, is reported. Methyl alpha-(p-hydroxyphenyl)propionate(5) was prepared from Friedel-Crafts reaction of isopropoxy benzene with methyl alpha-chloro-alpha-(methylthio) acetate(1), followed by desulfurization, methylation and clevage of ether bond. Compounds(10a-d) were made from(5) by a sequence of nitration, reduction, formation of benzoxazole ring, and hydrolysis in good yields, respectively.
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