7-[(3-메틸티오 또는 3-메틸티오메틸)-3-피롤리닐]퀴놀론-3-카르복실산의 합성과 항균작용

Synthesis and Antimicrobial Activity of 7-[(3-Methylthio or 3-Methylthiomethyl)-3-pyrrolinyl]quinolone-3-carboxylic Acids

A number of 7-[(3-methylthio or methylthiomethyl)-3-pyrrolinyl]quinolone-3-carboxylic acids were synthesized by condensation of 7-fluoro substituted quinolone-3-carboxylic acid with 3-methylthio-3-pyrroline or 3-methylthiomethyl-3-pyrroline. The in vitro antimicrobial activity of them were tested against twenty species of Gram-positive or Gram-negative microorganisms. It showed remarkable antibacterial activity, particularly against Gram-positive microorganisms. Among those 1-cyclopropyl-6,8-difluoro-7-[(3-methylthiomethyl)-3-pyrrolinyl]-l,4-dihydro-4-oxo-3-quinolinecarboxylic acid(12a) and 1-cyclopropyl-6-fluoro-8-chloro-7-[(3-methylthiomethyl)-3-pyrrolinyl]-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid(12b) showed the most potent in vitro antibacterial activity.