학술저널
(3aR*,6aS*)-6a-Hydroxy-cyclopenta[b]pyrrole-3a-carboxylate의 부제합성 및 NMR 스펙트럼을 통한 입체구조의 결정
- 대한약학회
- 약학회지
- 제38권 제5호 (1994년)
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1994.10544 - 554 (11 pages)
- 2
Pyrrolidine-2,3-dione derivative A was synthesized from oxalylation of chiral enamine Ba. The stereostructure of its major diastereomer (Amaj) was determined as octahydro-2,3-dioxo-6aS-hydroxy-1-(1S-methoxycarbonyl-2-phenylethyl)-cyclopenta[b]pyrrole-3aR-carboxylic acid ethyl ester Aa by means of NMR spectrum. This result implied that the asymmetric carbon-carbon bond forming reaction occurred preferentially at the beta-face of Ba.
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