학술저널
항암제인 Cyclophosphamide의 중간체인 15N-Isophosphoramide Mustard에 관한 연구
The Study of Cyclophosphamide Metabolite 15N-Isophosphoramide Mustard
- 대한약학회
- 약학회지
- 제38권 제6호 (1994년)
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1994.12673 - 676 (4 pages)
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The each nitrogen site of ifosfamide metabolite isophosphoramide mustard was synthesized with isotope enriched nitrogen. Gylcine-15N was converted to 2-chloroethylamine-15N hydrochloride which was then reacted with phenyl dichlorophosphate to provide N,N''-bis(2-chloroethyl)phosphordiamidic-15N2 acid phenylester(50%, PhO(O)15N(CH2CH2Cl2). Catalytic hydrogenation of this phenyl ester followed by the addition of cyclohexylamine (CHA) provided IPM-15N as the CHA salt(70%).
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