잔나비걸상 엑스의 생쥐 급성독성에 미치는 영향

Effect of Elfvingia applanta extract on the Acute Toxicity in Mice

To investigate the acute toxicity of Elfvingia applanata(Pers) KARST, it was extracted with hot water. EA, the aqueous extract from the carpophores of E. applanata, was lyophilized and a dark brownish powder was obtained. The acute toxicity of EA was investigated in ICR mice of both sexes. Five groups of mice were administered orally and intraperitoneally with 375, 750, 1,500, 3,000, 6,000mg/kg (p.o.) and 312.5, 625, 1,250, 2,500, 5,000mg/kg (i.p.) of EA. Abnormal clinical signs related to EA were not observed and no deaths occurred. LD50 values administered orally and intraperitoneally were evaluated to be over 6,000mg/kg and over 5,000mg/kg, respectively. Gross finding of necropsy revealed no evidence of specific toxicity related to EA. There were no significant changes in body weights, serum biochemical values and histopathological changes compared with control group.