학술저널
L-1,3-Dioxolane 및 L-1,3-Oxathiolane 피리미딘 뉴크레오사이드의 합성
Synthesis of L-1,3-Dioxolane and L-1,3-Oxathiolane Pyrimidine Nucleosides
- 대한약학회
- 약학회지
- 제38권 제6호 (1994년)
-
1994.12775 - 781 (7 pages)
- 2
(+/-)Dioxolane-T and(+/-)BCH-189 are know to possess anti-HIV activities, and less to xicities compared to other dideoxynucleoside AIDS drugs. We have synthesized 34 different enantiomerically pure nucleosides by glycosylation of L-1,3-dioxolanyl acetate and L-1,3-oxathiolanyl acetate sugar moieties with uracil or 6-azauracil with alkyl chains(C1-C3) on 5 or 6 position.
(0)
(0)