천연 페놀성 화합물들의 방향족 아미노산 탈탄산효소 저해 작용

Inhibition of Aromatic L-Amino Acid Decarboxylase (AADC) by Some Phenolic Compounds from Medicinal Plants

Sixteen kinds of naturally occurring phenolic compounds including 5 stilbenes, 7 flavonoids and 4 anthraquinones were examined in the inhibitory activity against rat liver AADC(aromatic L-amino acid decarboxylase) in vitro, using 5-hydroxytryptophan as a substrate. Three hydroxystilbenes, resveratrol 1, rhapontigenin 3 and piceatanol 5, which were known to be monoamine oxidase A inhibitors, exhibited a significant inhibition against AADC(IC50 = 20, 8 and 5 pM, respectively). By the comparison of the activity of each phenolic compound, it was suggested that the 3'',4''-dihydroxyphenyl group of stilbenes or flavones was the best pharmacophore for the AADC inhibitory activity.