흰쥐의 만성궤양 모델에서 Aceglutamide aluminium를 함유한 복합제산제의 점막방어인자 증강작용

Enhancing Effect of the Combined Preparation Containing Antacid and Aceglutamide on Defensive Factors in Chronic Ulcer Model of the Rat

Antacid(AM, 600mg/kg=aluminium hydroxide, magnesium hydroxide, and simethicone with a ratio of 1 : 1 : 0.1) and aceglutamide aluminium(AGA, 263 mg/kg)-Effect of the combined preparation containing on the gastric mucosal hexosamine, sialic acid, and aluminium contents adhered to the gastric wall of the rat was investigated. Severe ulcers were produced in rats by injecting of 30mcl acetic acid(30%) into the subserosal layer of one position in the corpus. When given orally for 15 consecutive days, AM(1,200mg/kg), AGA(525, 1,050mg/kg), and the combined preparation significantly decreased the ulcer area. AGA(525, 1,050mg/kg) and the combined preparation also increased the amount of hexosamine and sialic acid in the intact and ulcerated areas. On the other hand, the contents of hexosamine and sialic acid were not affected by AM (600, 1,200mg/kg). The amount of aluminium adhered to the gastric wall of the rat was higher in the combined preparation when compared to the AM(600mg/kg) and AGA(263mg/kg). The aluminium contents adhered may play an important role protecting mucosa from aggresive action of gastric juice and patenting defensive factors through the increase of mucosa-forming components by AGA.