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7,8번 위치에 이중결합을 갖는 10-membered lactone의 효율적인 합성

Efficient Synthesis of 10-Membered Lactone Possessing Ring-olefin at 7,8-Position

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An unusual 10-membered lactone possesing ring-olefin at 7,8-position has been efficiently synthesized. The w-hydroxy acid as a cyclization precusor was derived from epsilon-caprolactone in 41% overall yield of 7 steps and efficiently cyclized by Mukaiyama procedure.

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