학술저널
Computer Graphics: Quinolone계 항균제의 DNA-Interacalator에 관한 이론적 연구
Computer Graphics: Theoretical Study of Antibacterial Quinolone Derivatives as DNA-Intercalator
- 대한약학회
- 약학회지
- 제39권 제1호 (1995년)
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1995.0278 - 84 (7 pages)
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Based on Computer graphics molecular modeling method, quinolone derivatives as DNA-gyrase inhibitors formed stable DNA-intercalation complex with deoxycytidilyl-3'',5''-deoxyguanosine[d(CpG)2] dinucleotide. When d(CpG)2 and d(ApT)2 were compared in order to find out which DNA could form more stable DNA-Drug complex based on interaction energy and DNA-Drug complex energy, d(CpG)2 resulted in lower energy than d(ApT)2.
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