비모수적 기대최대치(NPEM) 연산방법에 의한 미국인과 재미동포 충수돌기염 환자에게 겐타마이신의 모집단 약물동태학

Population Pharmacokinetics for Gentamicin in American and Korean-American Appendicitis Patients Using Nonparametric Expected Maximum(NPEM) Algorithm

Population pharmacokinetics for gentamicin were compared with 24 American patients (16 male and 8 female) and 16 Korean-American appendicitis patients(12 male and 4 female). Two to six blood specimens were collected from all patients at the following times: just before a regularly scheduled infusion and at 1/2 hour after the end of a 1/2 hour infusion. Nonparametric expected maximum(NPEM) algorithm for population modeling was used. The estimated parameters were the elimination rate constants(K), the slope of the relationship between K versus creatinine clearance(KS), the apparent volume of distribution(V), the slope of the relationship between V versus weight(VS), gentamicin clearance(CL) and the slope of the relationship between CL versus creatinine clearance and the VS(CS). The output includes a 3-dimensional plot of the joint probability density function(PDF), two marginal PDF, means, medians, modes, variance, skewness, kurtosis, and CV%. The mean K(KS) were 0.424 +/- 0.139(0.00429 +/- 0.00164) and 0.411 +/- 0.135 hr-1 (0.00475 +/- 0.00180[hr.mL/min/1.73 m2]-1) for American and Korean-American populations, respectively. The mean V(VS) were not different at 15.6 +/- 4.77(0.233 +/- 0.0526) and 15.1 +/- 3.84L(O.239 +/- 0.0492L/kg) for American and Korean-American populations, respectively (P>0.2). The mean CL(CS) were 6.28 +/- 1.85(0.0634 +/- 0.0191) and 5.70 +/- 1.77L/hr(0.0701 +/- 0.0215L/kg[hr.mL/min/1.73m2]) for American and Korean-American populations, respectively. There are no differences in gentamicin pharmacokinetics between American and Korean-American appendicitis patients.