연명피 사포닌의 독성 및 용혈작용

Toxicity and Hemolytic Activitiy of Saponin Isolated from Sapindus mukorossi

Saponin isolated from Sapindus mukorossi Gaertn has been shown to contain a strong anti-inflammatory activity. In this study, several pharmacological properties such as acute toxicity, local irritation and hemolytic activity of Sapindus saponin and its genin component, hederagenin, were examined. The acute toxicity of Sapindus saponin was very low. Estimated from the LD50 values, it showed much weaker toxicity in oral administration than in intraperitoneal injection. Hederagenin gave a very high LD50 value even in intraperitoneal injection. Sapindus saponin showed a potent local irritation after topical application, whereas hederagenin did a very weak local irritation. Sapindus saponin also gave a high hemolytic activity.