Fluoroquinolone계 항생제인 DWQ-217의 in vitro와 in vivo 항균작용

Evaluation of in vitro and in vivo Antibacterial Activity of DWQ-217, a Fluoroquinolone

The in vitro and in vivo antibacterial activities of DWQ-217 (1-cyclopropyl-6-fluoro-8-chloro-7-(3-amino-4-methylthiomethylpyrrolidinyl)-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid) were compared with those of ciprofloxacin (CPFX) and vancomycin(VCM). DWQ-217 was superior to those of CPFX and VCM against gram positive bacteria. DWQ-217 showed excellent activity against MRSA (MIC of methicilline; >or= 12.5mcg/ml), MIC90=0.013. DWQ-217 possessed strong bactericidal action against gram positive and gram negative strains by MIC/MBC test and killing curve. DWQ-217 and CPFX were administered orally and subcutaneously to mice infected systemically with S. aureus and S. pyogenes. DWQ-217 was >or= 5-16 fold(p.o.) and >or= 3-5 fold(s.c.) more active than CPFX.