흰쥐에 있어서 Fthalide의 독성

The Toxicity of Fthalide in Rats

The acute toxicity of fthalide in rat was studied in vivo by the observations of the changes in hematogram, serological parameters, content of cytochrome p-450, activities of NADPH-cytochrom c reductase, glucose-6-phosphatase and the contents of cholinesterase and carboxylesterase in liver. Fthalide is a practically non-toxic substance(LD50 is 3.86g/Kg), but rats were intoxicated with fthalide at a oral dose of 100mg/kg for 12 days. WBC were significantly decreased and activities of ALT and LDH, on the contrary, the content of glucose in serum were slightly increased. Cytochrome p-450 and lipid peroxide in liver were significantly increased in the fthalide-intoxicated rats. The longer administration of fthalide showed further increase of carboxylesterase activity in liver and serum, but decrease of activities of glucose-6-phosphatase and cholinesterase in liver and serum. These results show that fthafide can induce the hepatocellular injury and neurotoxicity.