재조합 인간 상피세포 성장인자(DWP 401)의 일반약리작용

General Pharmacology of DWP 401, a Recombinant Human Epidermal Growth Factor

The recombinant human epidermal growth factor(DWP 401) was investigated on the pharmacological actions. DWP 401 had no effects on the hexobarbital-induced sleeping time, locomotor activity, rotarod test, body temperature, analgesic action and anticonvulsant action in mice. It also had no influences on the isolated tracheal muscle and ileum of guinea-pig, isolated uterus and fundus strip of rats. Slight hypotensive action with effect on respiration was revealed at a dose of 8g/kg i.v. of DWP 401 in rabbits. DWP 401 exhibited a weak inhibitory action of glucose tolerance in normal rats, significantly lowered the blood glucose contents in adrenalectomized rats at a concentration of 160g/kg, and produced a significant inhibitory effect on leucocyte migration in CMC-pouch of rats at a concentration of 32g/rat. Furthermore, DWP 401 showed a significant decrease on gastric juice volume and acidity. However, DWP 401 had no intestinal propulsion rate and influence on urine excretion.