납이온이 잔틴 옥시다제 활성에 미치는 영향

Effect of Lead Ion on the Hepatic Xanthine Oxidase Activity in Vitro

This study was done to determine the effect of lead acetate on the activities of the hepatic cytosolic xanthine oxidase and aldehyde oxidase which were well known as oxygen free radical generating enzyme in vitro. Lead ion accelerated the formation of lipid peroxide and the increment of xanthine oxidase(type O) activity and the type conversion ratio from xanthine dehydrogenase to xanthine oxidase dose-dependently. But xanthine dehydrogenase(type D) activity was decreased. Aldehyde oxidase activity was not changed by lead ion. These data suggested that lead-induced cellular toxicity may be concerned partially with xanthine oxidase mediated lipid peroxidation.