학술저널
아스파라톤에 의한 사이클로옥시나제의 저해 - in Vitro
In Vitro Inhibition of Cyclooxygenase by Aspalatone
- 대한약학회
- 약학회지
- 제39권 제5호 (1995년)
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1995.10565 - 568 (4 pages)
- 1
A new antiplatelet agent, aspalatone ([3-(2-methyl-4-pyronyl)]-2-acetyloxybenzoate) was demonstrated to inhibit MDA generation from arachidonic acid catalyzed by partially purified bovine seminal vesicle cyclooxygenase. This inhibition was also observed with acetylsalicylic acid. The results suggest that the mechanism for the antiplatelet effect of aspalatone is, like acetylsalicylic acid, due to its inhibition of cyclooxygenase.
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