흰쥐에서 제산제와 병용투여된 아세글루타미드 알루미늄의 약물동태 및 위장관 부착

Pharmacokinetics and Gastric Adhesion of Aceglutamide Aluminium on The Combination of Antacid in Rats

On the combination of antacid, the pharmacokinetics and gastric adhesion of [14C]aceglutamide aluminium complex([14C]AGA) were examined in rats. Specially, this study was focused on the drug interaction that the co-administration of anatacid may affect the oral co-administration of [14C] AGA and antacid(aluminium hydroxide and magnesium hydroxide(AM)), the radioactivity of plasma and urinary recovery was lower than that of [14C]AGA alone administered group. However, the cumulative recovery of radioactivity in feces was increased significantly. The comparative bioavailability of [14C]AGA from the plasma concentration-time curve and urinary recovery was about 60%. In vitro, the effect of antacid on the gastric adhesion of AGA was not significantly different between AGA and AGA/antacid treatment. And it accorded well with the result of in vivo experiment. In conclusion, on the combination of antacid , the oral absorption of AGA was decreased but the gastric adhesion was not affected in respect of drug interaction.