학술저널
2-Acetyl-11-Keto-deltal2 : 13-Oleanolic Ketol Acetate 급 기타 유도체의 합성
Synthesis of 2-Acetyl 11-keto delta12:13 Oleanolic ketol acetate and other derivatives.
- 대한약학회
- 약학회지
- 제6권 제1호 (1962년)
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1962.0525 - 27 (3 pages)
- 2
The derivative of glycyrrhetinic acid which have similar effects of desoxycorticosterone acetate was prepared glycyrrhetinyl chloride by the chlorination with thionyl chloride at low temperature. 2-Acetyl-11-keto-delta12 : 13 oleanolic ketol acetate (30) was synthesized by diazotating glycyrrhetinyl chloride with diazomethan and the acetylation with anhydro acetic acid. 2-Acetyl-delta12 : 13 oleanolic ketoi acetate (28) was synthesized by chlorinating oleanolic acid with thionyl chloride, and by diazotating oleanolyl chloride with diazomethan and the acetylation with anhydroacetic acid.
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