Lycoctonum 속식물성분의 약리학적연구 I

Pharmacological Study of Components of L. pseudo-laeve Nakai.

Crystal A and B were isolated from L. pseudo-laeve Nakai and their pharmacological action was observed. Crystal A, in dose of 5 X 10-4 ~ 5 X 10-5g/ml, stimulated excised frog heat but at 2.5 X 10-6 ~ 0.5 X 10-5g/ml of crystal B, depressant effect was observed. Mild stimulation of rhythmicity of excised rabbit intestine was produced by 1 X 10-4g/ml of crystal A and 2 X 10-5g/ml of crystal B. Marked depression of tone was produced by 2 X 10-4g/ml of crystal A, antagonizing by pilocarpine. Crystal B(4 X 10-4gm/1) produced mild stimulation, followed by depression of tone. No curare-like action on excised frog abdominal muscle was elicited with both substances.