p-Methoxycinnamic Acid의 뇨대사물에 대하여

Urinary Metabolites of p-Methoxycinnamic Acid

The metabolism of p-methoxycinnamic acid (p-MCA) has been studied in man and rabbits. Possible compounds were examined for metabolites by crystalization and bv paper chromatography, which excreted alter administration of p-MCA by stomach tube and intravenous injection. p-Methoxyhippuric acid was isolated from urine. Although pure glucuronide was not crystallized from urine, product was obtained by basic lead salt method, which gave p-methoxybenzoic acid (p-MBA) on hydrolysis and gave an intense naphthoresorcinol reaction. No evidence for the demethylation of p-MCA was found. These results are indicating that p-MCA may be mainly converted to p-MBA by beta-oxidation and excreted as its conjugates with glycine and glucuronic acid. Its oxidation does not appear to be dependent on intestinal micro-organisms.