학술저널
Dimethylformamide 수용액중에서의 Sulfa제-Cu 착화합물의 안정도정수
Stability Constants of Copper Sulfa-Drug Complexes in Dimethylformamide Aqueous Solution
- 대한약학회
- 약학회지
- 제9권 제1&2호 (1965년)
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1965.064 - 7 (4 pages)
- 2
Acid dissociation constants of sulfamethoxypyridazine, sulfadimethoxine, sulfamerazine, sulfathiazole and sulfadiazine, and stability constants for formation of copper chelate were calculated from their titration curves in 80% dimethylformamide with ionic strength 0.1 at 25o It was found that the acid dissociation constants (pKa) of sulfa-drugs were in the range of 9.33~10.05, and the stability constants (log k1, k2) of their copper chelates were in the range of 9.33~9.71.
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