p-Methoxycinnamic Acid의 진통작용

Analgesic Action of p-Methoxycinnamic acid.

In the previous papers, it was reported that p-methoxycinnamate showed good antipyretic action when tested on the typhoid-vaccinated rabbits and decreased the ascorbic add content of the adrenals of rats like other wellknown antipyretics. In the present work, it was shown that p-methoxycinnamic acid exhibited marked analgesic properties. The method employed for testing analgesic effect was modification of that described by Woolfe and Macdonald. Of mice which had been trained and jumped out within 5 seconds on the hot plate of 59o, the reaction time was prolonged by subcutaneous injection of its sodium salt aqueous solution. Mean responses were proved to increase linearly with the log doses (from doses 160mg to 500mg/kg).