2-(5-nitro)furylacrylic acid류의 합성 및 항균작용에 관한 연구

Studies on the Synthesis and Antibacterial Actionof 2-(5-nitro)furylacrylic acids

In order to find 2-(5-nitro)furylacrylic acid derivatives possessing antimicrobial activity, nine new 2-(5-nitro)furylacrylamino acids were synthesized which were obtained by the action of 2-(5-nitro)furylacryl chloride on amino acids, such as L-phenylalanine, glycine, L-isoleucine, L-glutamic acid, DL-methionine, L-threonine, L-valine, L-tryptophan and DL-alanine, according to Schotten-Baumann method. These compounds generally showed a good bactericidal and bacteriostatic activity against Bacillus subtilis but were less effective against staphylococcus aureus, Proteus vudgaris and Escherichia coli. Of the above nine compounds, 2-(5-nitro)furylacryl glycine exhibited a good bactericidal activity.