호라비꽃대(급기) Chloranthus Japonica Sieb.의 성분에 관한 연구 (I) 결정성분의 분리 및 항균작용

Studies on Chemical Components of Chloranthus japonica Sieb (I) Isolation of crystal substance and its antibacterial activity

It has been believed that "Kup kee" (Chloranthus japonica) is good for boils, or dermatopathia, and enteric fever by the Korean folks. However, there is no scientific report on its chemical ingredients and its antibacterial activities so far. The roots of Chloranthus japonica were dried and pulverized. The pulverized powder was then extracted with methanol. Then an extract was obtained by following Stas Otto''s method. Finally a crystal fraction was obtained through Column Chromatography. Recrystalization from methanol gave white needle crystals, m.p. 198oC. Generally this compound has shown strong antibacterial effect on Gram negative bacteria. It exerts most powerful effect on Salmonella typhi. on the other hand it shows weak effect on Inaba cholera.