N,N''-Disubstituted Thiourea Derivatives의 합성과 항균성, 항인결핵성 및 항종양 시험에 관한 연구

Studies on the Synthesis of N,N''-Disubstituted Thiourea Derivatives and their Antibacterial, Antitubercular and Antitumor Activities

Seventeen N,N''-disubstituted thiourea derivatives were synthesized by the Hugershof reaction and reported. Antitumor activities of the synthesized compounds against ascitic Ehrlich Carcinoma and ascitic Sarcoma 180 were reported. It was found that 1,11-(p-Phenylene)-3,3''-bis (2-carboxyphenyl)-2,2''-dithiourea was considerably active against ascitic Ehrlich Carcinoma and Sarcoma 180 respectively. 1-(2-Carboxyphenyl)-3-(p-ethoxyphenyl)-2-thiourea was active against ascitic Sarcoma 180. 1-Salicyloyl-3-(p-ethoxyphenyl)-2-thiourea and 1,1''-(p-Phenylene)-3,3''-bis(2-hydroxyethyl)-2,2''-dithiourea were active against ascitic Ehrlich Carcinoma. Antitubercular activities of the synthesized compounds against Mycobacterium tuberculosis H37 Rv were also reported. It was found that 1-Isonicotinyl-4-cyclohexyl-3-thiosemicarbazide was considerably active at 100mcg/ml. 1,1''-(p-Phenylene)-3,3-bis(2-hydroxyethyl)-2,2''-dithiourea and 1-Salicyloyl-3-(p-ethoxyphenyl)-2-thiourea were active at 100mcg/ml respectively. Antibacterial activities of nine compounds of t he synthesized compounds against S. aureus and E. Coli were reported. It wes found that 1,1-(p-Phenylene)-4,4''-bis(isonicotinyl)-2,2''-dithiosemicarbazide and 1-Isonicotinyl-4-cyclohexyl-3- thiosemicarbazied were considerably active against S.aureus and E.Coli respectively. 1-(6-Methyl-2-benzathiazolyi)-3- (1-n-aphthyl)-2-thiourea was active against S. aureus. 1,1''-(p-Phenylene)-3,3''-bis (2-hydroxyethyl)-2,2''-dithiourea was active against E.Coli.