한국산산형료식물의 성분연구(IX) Isomperatorin 및 Oxypeucedanin의 일반약리작용

Studies on the Components of Umbelliferous Plants in Korea(IX). Pharmacological Study of Isoimperatorin and Oxypeucedanin

Isoimperatorin and Oxypeucedanin isolated from root of Angelica koreana Max.(Umbelliferae) that is used as "Kang-Whal"(강활) a botanical drug, in Korea, Show following general pharmacologic activities. The treatment with Oxypeucedanin on the excised duodenum of the rabbit increased the motility of it while isoimperatorin shows little effects. But on the excised heart of the frogs, both components depressed its contractility. Whereas Oxypeucedanin depressed both blood pressure of the carotied artery and respiration of the rabbit, Isoimperatorin tends to increase blood pressure, respiration and the tonus of the muscle of the earth worm. Oxypeucedanin did not affect the tonus of the muscle of the earth worm, but depressed the uterus contraction of the rabbit, which was, on the contrary, increased by Isoimperatorin.