Aminopyrine.항히스타민 제혼합물의 흡수에 관한 연구

Studies on the Absorption of Mixed Compounds of Aminopyrine Antihistamic Agent

The absorption of Aminopyrine from the small intestine of a rat in combination with antihistamic agent, Diphenhydramine, Pheniramine, Tripelennamine and Diphenhydramine respectively, was examined. Through the rat small intestine canal, a definite quantity of a sample solution comprising 0.5mM of Aminopyrine and 0.1mM of each antihistamic agent in phosphate buffer solution (pH=7.4) was perfused through the rat small intestine at rate 5ml per minute. The samples of the circulating solution were taken out after 5 minutes of the perfusion to give initial concentration and every 30 minutes for 3 hours. The amount of residual Aminopyrine in the solution was determined photometrically at 720mmc by using 0.4% potassium ferricyanate solution and 1% ferric nitrate in O.1N nitric solution. The mixed compounds of Aminopyrine with antihistamic agent, such as Aminopyrine with Diphenhydramine, Aminopyrine with Pheniramine, Aminopyrine with Tripelennamine and Aminopyrine with Chlorpheniramine showed more increased absorption than Aminopyrine alone. The absorption rate constants and apparent permeability co-clecients of the mixed compounds were shown in detail.