조혈제 제조에 관한 연구 III 지효성제형화에 대하여

Study on the Preparation of Ferruginous Hematinics. III. A Study on the Preparation of Sustained-Release Formed Ferruginous Hematinics

In order to compare the iron concentrations of the marketed ferruginous hematinics with the sustained-release dosage forms and to prepare the good hematinic which can be absorbed effectively without forming "iron block" in the gastrointestinal tract, gelatinized micropellets containing medicament were prepared and hardened in 10% formalin-isopropanol in the time of 72 hours. These micropellets were digested with artificial gastric juice and plotted a curve of released iron concentration. As a result, it is found that gelatinized micropellets sustained-release dosage form is an excellent ferruginous hematinic and it is shown that several marketed preparations can be improved in their hematinic actions by forming the sustained-release dosage.