화학요법제합성연구 N-(Substituted-2-benzothazolyl) Acid Amided의 합성 및 그 항균성과 항인결핵성

Synthetic Studies on Chemotherapeutic Agents. I. Synthesis and their Antimicrobial and Antitubercular Activity of N-(6-Substituted-2-benzothiazolyl) Acid Amides

Nine novel compounds, namely, 2-(p-aminobenzenesulfonamido)-6-sulfamylbenzothiozole, 2-benzamido-6-sulamylbenzothiazole, 2-(p-toluenesulfonamido)-6-sulfamylbenzothiazole, 2-(3, 5-dinitrobenzamido)-6-sulfamylbenzothiazole, 2-benzamido-6-nitrobenzothiazole, 2-(p-toluene-sulfonamido)-6-nitrobenzothiazole, 2-(3, 5-dinitrobenzamido)-6-nitrobenzothiazole, 2-(p-toluenesulfonamido)-6-chlorobenzothiazole, 2-(3, 5-dinitrobenzamido)-6-chlorobenzothiazole were synthesized and evaluated for their in vitro antimicrobial activity against Staphylococcus aureus wood 46, beta-Streptococcus S86, Escherichia coli and antitubercular activity against Mycobacterium tuberculosis H37Rv. 2-(p-Toluenesulfonamido)-6-chlorobenzothiazole showed antimicrobial activity at 25mcg/ml against beta-Streptococcus S/86, 2-(3,5-Dinitrobenzamido)-6-sulfamylbenzothiazole was active at 5mcg/ml and 2-(3,5-dinitrobenzamido)-6-nitrobenzothiazole was considerably active at lmcg/ml against Mycobacterium tuberculosis H37Rv.